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Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. [3] This may be done if the blood pressure is very high and resulting in symptoms , in certain types of heart failure , and during surgery to decrease bleeding . [ 3 ]
For quick action in the treatment of angina, glyceryl trinitrate is used in form of a sublingual spray (nitro spray) or as soft capsules to be crunched. [4] Nitroprusside is used intravenously for the treatment of hypertensive crises, heart failure, and lowering of blood pressure during surgery. [5] [6]
Nitroglycerin was written about as early as 1846 [5] [6] and came into medical use in 1878. [7] [8] [9] The drug nitroglycerin is a dilute form of the same chemical used as the explosive, nitroglycerin. [9] Dilution makes it non-explosive. [9]
Nitroglycerin (NG) (alternative spelling nitroglycerine), also known as trinitroglycerol (TNG), nitro, glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane, is a dense, colorless or pale yellow, oily, explosive liquid most commonly produced by nitrating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester.
A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. [3] Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there.
As with all supplements of nitric oxide, the response is short-lived because, as a normally produced internal physiologic control mechanism, increased concentrations lead to increased rates of clearance, which is the reason that the effectiveness of sustained use of nitroglycerin for vasodilation fades to none after hours to days.
The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar and an R group. [4] The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity. [4]
The reagent is typically provided in two parts: [2] [1] [3] A mixture of 2% sodium nitroprusside and 2% acetaldehyde in water (solution A) [4] A solution of 2% sodium carbonate in water (solution B) [4] Separate storage of the aldehyde and base are necessary to prevent aldol polymerisation of the aldehyde.
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