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[42] c-KIT- and PDGFRA-mutation negative GIST tumors are usually resistant to treatment with imatinib, [16] as is neurofibromatosis-1-associated wild-type GIST. [37] A specific subtype of PDGFRA mutation, D842V, is also insensitive to imatinib. [37] [43] Recently, in PDGFRA-mutated GIST, avapritinib has been approved by FDA. [44]
The prognosis for these types of tumors depends heavily on the size of the tumor and the rate of mitosis, however approximately 60 percent of GISTs are diagnosed as benign. [4] Surgery to remove the tumor is the primary treatment method, although imatinib, everolimus, and rapamycin may soon be approved as alternative treatment and management ...
Exposition Park is a 160-acre urban park (65 ha) in the south region of Los Angeles, California, [1] in the Exposition Park neighborhood. Bounded by Exposition Boulevard to the north, South Figueroa Street to the east, Martin Luther King Jr. Boulevard to the south and Vermont Avenue to the west, it is directly south of the main campus of the ...
The historic Mission Revival style Exposition Club House, a Los Angeles Historic-Cultural Monument.. A total of 31,062 residents counted in its 1.85 square miles, which is including the park land as well as Los Angeles Memorial Coliseum according to the 2000 U.S. census—an average of 16,819 people per square mile among the highest population densities for both the city and the county.
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(Michael Blackshire / Los Angeles Times) Prosecutors announced murder charges Monday against a 33-year-old man who allegedly shot and killed two brothers earlier this month near Exposition Park.
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Two brothers were fatally shot Saturday afternoon while sitting in a car in a residential area of Exposition Park, and the shooter is at large, Los Angeles police said.
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