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Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
Excel graph of the difference between two evaluations of the smallest root of a quadratic: direct evaluation using the quadratic formula (accurate at smaller b) and an approximation for widely spaced roots (accurate for larger b). The difference reaches a minimum at the large dots, and round-off causes squiggles in the curves beyond this minimum.
NodeXL integrates into Microsoft Excel 2007, 2010, 2013, 2016, 2019 and 365 and opens as a workbook with a variety of worksheets containing the elements of a graph structure such as edges and nodes. NodeXL can also import a variety of graph formats such as edgelists, adjacency matrices, GraphML , UCINet .dl, and Pajek .net.
A medical algorithm is any computation, formula, statistical survey, nomogram, or look-up table, useful in healthcare. Medical algorithms include decision tree approaches to healthcare treatment (e.g., if symptoms A, B, and C are evident, then use treatment X) and also less clear-cut tools aimed at reducing or defining uncertainty.
All such algorithms proceed in two steps: The initial, "prediction" step, starts from a function fitted to the function-values and derivative-values at a preceding set of points to extrapolate ("anticipate") this function's value at a subsequent, new point.
Powell's method, strictly Powell's conjugate direction method, is an algorithm proposed by Michael J. D. Powell for finding a local minimum of a function. The function need not be differentiable, and no derivatives are taken. The function must be a real-valued function of a fixed number of real-valued inputs. The caller passes in the initial point.
Gain-of-function mutations in the gene ACVR1/ALK2 is responsible for the genetic disease fibrodysplasia ossificans progressiva (FOP). [10] The typical FOP patient has the amino acid arginine substituted for the amino acid histidine at position 206 in this protein.
POH was discovered as a distinct condition when Kaplan was investigating FOP. Some of the patients initially diagnosed with FOP were found to have a distinctly different manifestation of symptoms, though, like FOP, the disease still resulted in heterotopic ossification (formation of bone tissue outside the skeleton). None of the patients had ...