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The aims of EULAR are to reduce the burden of rheumatic diseases on the individual and society and to improve the treatment, prevention and rehabilitation of musculoskeletal diseases. It promotes the translation of research advances into daily care and fights for the recognition of the needs of people with musculoskeletal diseases by the ...
Sifalimumab is a human monoclonal antibody designed for the treatment of SLE, dermatomyositis, and polymyositis. [1] It targets interferon a. [2] Sifalimumab was developed by MedImmune; as of 2017 development had been terminated in favor of moving a competing internal product, anifrolumab, into Phase III trials. [3] [4] [5]
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. [1] Symptoms vary among people and may be mild to severe. [ 1 ]
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases. [3] [4] It is a type of glomerulonephritis in which the glomeruli become inflamed.
Department of Electricity Development (Nepali: विद्युत विकास विभाग) under Ministry of Energy, Water Resources and Irrigation is the authority to implement the government policies related to power/electricity sector. [1]
Epratuzumab binds to the glycoprotein CD22 of mature and malignant B-cells.. Elevated CD22 and other B-cell receptor (BCR) proteins are associated with SLE. "Epratuzumab's mechanism of action transfers these BCR proteins to helper cells called effector cells which reduces B-cell destruction and epratuzumab's impact on the body's immune system" [6] via a process called trogocytosis. [3]
Nepal Bureau of Standards & Metrology (NBSM) is a department under the Ministry of Industry, Nepal. [1] The department was established in 1976 based on the Industrial policy (1974) with an aim to regulate and improve the quality of industrial production. The initial name of the department was Nepal Institute of Standards (NIS).
The Department of Local Infrastructure Development (DoLID), is a department under the Ministry of Urban Development of Nepal, responsible for assisting local governments in the engineering aspects of civil engineering construction including rural, urban and agriculture road/bridge construction and mentinance. [1] It has its branch offices. [2] [3]