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If levels of mineralocorticoids are decreased, then there are lower circulating levels to compete with spironolactone to influence gene expression as mentioned above. [23] The onset of action of the antimineralocorticoid effects of spironolactone is relatively slow, with the peak effect sometimes occurring 48 hours or more after the first dose ...
Spironolactone can cause hyperkalemia, or high blood potassium levels. [111] Rarely, this can be fatal. [111] Of people with heart disease prescribed typical dosages of spironolactone, 10 to 15% develop some degree of hyperkalemia, and 6% develop severe hyperkalemia. [111] At a higher dosage, a rate of hyperkalemia of 24% has been observed. [119]
Chapped lips (also known as cheilitis simplex [5] or common cheilitis) [6] is characterized by the cracking, fissuring, and peeling of the skin of the lips, and is one of the most common types of cheilitis. [5] [7] While both lips may be affected, the lower lip is the most common site. [7]
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Allergic reactions are a relatively common cause of throat swelling in general, but sometimes the uvula can be affected alone. “This is known as uvular angioedema,” says Dr. Morrison.
Infections involving the salivary glands can be viral or bacterial (or rarely fungal). Mumps is the most common viral sialadenitis. It usually occurs in children and involves pain in front of the ear, swelling of the parotid, fever, chills, and headaches. [2] Bacterial sialadenitis is usually caused by ascending organisms from the mouth.
It can also be itchy or painful. [2] The condition can last for days to years. [2] Angular cheilitis is a type of cheilitis (inflammation of the lips). [6] Angular cheilitis can be caused by infection, irritation, or allergies. [2] Infections include by fungi such as Candida albicans and bacteria such as Staph. aureus. [2]
Furthermore, additional laboratory testing can be done to consider other causes of swelling that appear similar to angioedema. [2] Some of the common differential diagnoses for angioedema include: allergic reactions , contact dermatitis , skin and soft tissue infections (i.e. cellulitis ), lymphedema , and foreign body aspiration .