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Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
Other, non-cardiovascular risk factors include obesity, diabetes, and excessive alcohol consumption. Adding to all this, there also seems to be a genetic component as well. These factors likely stress the cells in the atria, which can lead to tissue heterogeneity, which means that cells start taking on different electrical properties.
The CHADS 2 score and its updated version, the CHA 2 DS 2-VASc score, are clinical prediction rules for estimating the risk of stroke in people with non-rheumatic atrial fibrillation (AF), a common and serious heart arrhythmia associated with thromboembolic stroke.
The decision to anticoagulate people with HF, typically with left ventricular ejection fractions <35% is debated, but generally, people with coexisting atrial fibrillation, a prior embolic event, or conditions that increase the risk of an embolic event such as amyloidosis, left ventricular noncompaction, familial dilated cardiomyopathy, or a ...
Risk factors for thromboembolism, the major cause of arterial embolism, include disturbed blood flow (such as in atrial fibrillation and mitral stenosis), injury or damage to an artery wall, and hypercoagulability [1] (such as increased platelet count). [2]
Risk factors include history of diabetes, coronary artery disease, tobacco use, atrial fibrillation, hypercoagulable disorders, autoimmune diseases, or diseases affecting connective tissues, such as Ehlers-Danlos syndrome. [14] In a patient with otherwise no known risk factors, atrial fibrillation with embolism should be suspected. [14]
Commonly encountered conditions that must be treated for and have independent recommendations for standard of care include atrial fibrillation, coronary artery disease, hypertension, and hyperlipidemia. There are particular factors unique to HFpEF that must be accounted for with therapy.
Those with atrial fibrillation have a 5% a year risk of stroke, and those with valvular atrial fibrillation have an even higher risk. [130] Depending on the stroke risk, anticoagulation with medications such as warfarin or aspirin is useful for prevention with various levels of comparative effectiveness depending on the type of treatment used ...
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