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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
2,5-Dimethoxy-4-isobutylamphetamine (DOIB or DOiBu) is a serotonin 5-HT 2A receptor agonist, serotonergic psychedelic, and anti-inflammatory drug of the ...
However, those acting as serotonin 5-HT 2 receptor agonists have been found to induce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. [ 2 ] These findings suggest that substituted benzothiophenes may have entactogenic and/or psychedelic effects in humans whilst lacking stimulant effects and possibly having ...
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meta-Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is an allosteric agonist and modulator of the 5-HT 3 receptor [1] [2] [3] and an antagonist of the α 2A-adrenergic receptor. [4] It has anxiogenic , emetic and hypothermic effects in animal studies.
In addition to the serotonin 5-HT 2A and 5-HT 2C receptors, BMB-A39a is a potent partial agonist of the serotonin 5-HT 1F and 5-HT 6 receptors. [3] Conversely, BMB-A39a shows minimal or negligible activity in activating the serotonin 5-HT 2B receptor ( E max < 20%) and does not activate other serotonin receptors .
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