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The Purkinje layer of the cerebellum, which contains the cell bodies of the Purkinje cells and Bergmann glia, express a large number of unique genes. [9] Purkinje-specific gene markers were also proposed by comparing the transcriptome of Purkinje-deficient mice with that of wild-type mice. [10]
The Purkinje fibers are further specialized to rapidly conduct impulses (having numerous fast voltage-gated sodium channels and mitochondria, and fewer myofibrils, than the surrounding muscle tissue). Purkinje fibers take up stain differently from the surrounding muscle cells because of having relatively fewer myofibrils than other cardiac cells.
Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell. These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory ...
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum.The nuclei are the fastigial, globose, emboliform, and dentate nuclei.. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus.
Each Purkinje cell receives excitatory input from 100,000 to 200,000 parallel fibers. Parallel fibers are said to be responsible for the simple (all or nothing, amplitude invariant) spiking of the Purkinje cell. Purkinje cells also receive input from the inferior olivary nucleus via climbing fibers. A good mnemonic for this interaction is the ...
Cerebellar basket cell axons fire inhibitory neurotransmitters such as GABA to Purkinje cell axons, and inhibits the Purkinje cell. [9] Purkinje cells send inhibitory messages to the deep cerebellar nuclei and are responsible for the sole output of motor coordination from the cerebellar cortex. With the work of the basket cell, Purkinje cells ...
Jan Evangelista Purkyně (Czech: [ˈjan ˈɛvaŋɡɛˌlɪsta ˈpurkɪɲɛ] ⓘ; also written Johann Evangelist Purkinje) (17 or 18 December 1787 – 28 July 1869) was a Czech anatomist and physiologist. In 1839, he coined the term "protoplasma" for the fluid substance of a cell. He was one of the best known scientists of his time.
GC: Granule cell. PF: Parallel fiber. PC: Purkinje cell. GgC: Golgi cell. SC: Stellate cell. BC: Basket cell. Mossy fibers are one of the major inputs to cerebellum. There are many sources of this pathway, the largest of which is the cerebral cortex, which sends input to the cerebellum via the pontocerebellar pathway.