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The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau disease, which is characterized by hemangioblastomas of the brain, spinal cord and retina. It is also associated with kidney and pancreatic lesions.
Von Hippel-Lindau (VHL) disease is classified into two main types based on the presence or absence of pheochromocytoma (pheo). VHL type 1 is characterized by the absence of pheo, while VHL type 2 encompasses individuals with pheo and is further divided into three subcategories: type 2A, type 2B, and type 2C. [19]
Pet Sounds is the eleventh studio album by the American rock band the Beach Boys, released on May 16, 1966, by Capitol Records.It was initially met with a lukewarm critical response in the United States, although it peaked at number 10 on the Billboard Top LPs chart.
As defined by the 2005 Act, large casinos can have a maximum of one hundred and fifty machines in any combination of categories B–D (subject to a machine-to-table ratio of 5:1); small casinos can have a maximum of eighty machines in any combination of categories B–D (subject to a machine-to-table ratio of 2:1).