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Murine polyomavirus (also known as mouse polyomavirus, Polyomavirus muris, or Mus musculus polyomavirus 1, and in older literature as SE polyoma or parotid tumor virus; abbreviated MPyV) is an unenveloped double-stranded DNA virus of the polyomavirus family. The first member of the family discovered, it was originally identified by accident in ...
Murine polyomavirus was the first polyomavirus discovered, having been reported by Ludwik Gross in 1953 as an extract of mouse leukemias capable of inducing parotid gland tumors. [84] The causative agent was identified as a virus by Sarah Stewart and Bernice Eddy , after whom it was once called "SE polyoma".
Murine polyomavirus (MPyV), described in the 1950s, was the first polyomavirus discovered and can cause tumors in rodents. MPyV has three early proteins; in addition to LTag and STag it also expresses middle tumor antigen , which is primarily responsible for the virus's transforming activity.
A map of the murine polyomavirus genome, indicating the early genes (LTag, MTag, and STag) at right in blue and the late genes (the viral capsid proteins) at left in red. . Each region is transcribed as a single messenger RNA and alternatively spliced to express multiple proteins; the exons are shown as thickened lin
Murine polyomavirus VP1 in complex with the GT1a glycan. GT1a is shown in yellow and the VP1 monomer with a white surface and a blue protein backbone. A complex network of hydrogen bonds, many water-mediated, is shown at the binding surface by orange lines, with participating protein residues shown as sticks. Mutations of the two residues shown ...
Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008 in Pittsburgh, Pennsylvania. [1] It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptome subtraction . [ 2 ]
Gross murine leukemia virus is a retrovirus whose human counterpart is T cell lymphotropic virus I, while murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. Thus, Gross identified two critical animal viruses that serve as models for viruses causing cancer in humans.
MMTV-PyMT is the model of breast cancer metastasis, in which MMTV-LTR is used to drive the expression of mammary gland specific polyomavirus middle T-antigen, leading to a rapid development of highly metastatic tumors. [45] MMTV-PyMT is the most commonly used model for the study of mammary tumor progression and metastasis.