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  2. File:Lac operon.pdf - Wikipedia

    en.wikipedia.org/wiki/File:Lac_operon.pdf

    You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made.

  3. lac operon - Wikipedia

    en.wikipedia.org/wiki/Lac_operon

    The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria.Although glucose is the preferred carbon source for most enteric bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of β-galactosidase. [1]

  4. Diauxic growth - Wikipedia

    en.wikipedia.org/wiki/Diauxic_growth

    Monod later put aside his work on diauxic growth and focused on the lac operon model of gene expression, which led to a Nobel prize. Diauxie occurs because organisms use operons or multiple sets of genes to control differently the expression of enzymes needed to metabolize the different nutrients or sugars they encounter. If an organism ...

  5. Synthetic biological circuit - Wikipedia

    en.wikipedia.org/wiki/Synthetic_biological_circuit

    They discovered that the mechanism that controlled the metabolic "switching" function was a two-part control mechanism on the lac operon. When lactose is present in the cell the enzyme β-galactosidase is produced to convert lactose into glucose or galactose. When lactose is absent in the cell the lac repressor inhibits the production of the ...

  6. Silencer (genetics) - Wikipedia

    en.wikipedia.org/wiki/Silencer_(genetics)

    The lac operon in the prokaryote E. coli consists of genes that produce enzymes to break down lactose. Its operon is an example of a prokaryotic silencer. The three functional genes in this operon are lacZ, lacY, and lacA. [6] The repressor gene, lacI, will produce the repressor protein LacI which is under allosteric regulation.

  7. Cis-regulatory element - Wikipedia

    en.wikipedia.org/wiki/Cis-regulatory_element

    An example of a cis-acting regulatory sequence is the operator in the lac operon. This DNA sequence is bound by the lac repressor, which, in turn, prevents transcription of the adjacent genes on the same DNA molecule. The lac operator is, thus, considered to "act in cis" on the regulation of the nearby genes.

  8. Catabolite repression - Wikipedia

    en.wikipedia.org/wiki/Catabolite_repression

    Absence of glucose will "turn off" catabolite repression. When glucose levels are low, the phosphorylated form of EIIA accumulates and consequently activates the enzyme adenylyl cyclase, which will produce high levels of cAMP. cAMP binds to catabolite activator protein (CAP) and together they will bind to a promoter sequence on the lac operon ...

  9. Beta-galactoside permease - Wikipedia

    en.wikipedia.org/wiki/Beta-galactoside_permease

    Galactoside permease is a protein coded by the lacY gene of the lac operon, and is found bound to the membrane of a cell for the purpose of binding galactoside molecules that have been solubilized. The protein is part of a system whose main function is to catalyze the accumulation and transport of lactose and other beta-galactosides across the ...

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