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The risks and possible side effects of the polio vaccine are comparable to those of other vaccines, the CDC says, such as pain, soreness, swelling, and/or redness at the injection site. Fainting ...
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The polio vaccines prevented 29 million cases of paralytic polio between 1960 and 2021, compared with a counterfactual world with no vaccines, according to researchers’ estimates.
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
Oral polio vaccine contains live attenuated (weakened) strains of the three serotypes of poliovirus. Passaging the virus strains in monkey kidney epithelial cells introduces mutations in the viral IRES, and hinders (or attenuates) the ability of the virus to infect nerve tissue. [26] Polioviruses were formerly classified as a distinct species ...
The second vaccine, an oral polio vaccine (OPV), is a live-attenuated vaccine, produced by the passage of the virus through non-human cells at a sub-physiological temperature. The passage of virus produces mutations within the viral genome, and hinders the virus's ability to infect nervous tissue. [6]
Racaniello said the vaccine is meant to keep people from getting sick rather than prevent the virus from entering our cells. But Orenstein said vaccines may still stave off some infections and ...
IPV stands for inactivated poliovirus vaccine, which means that it does not use a live strand of the polio virus and cannot result in polio. [8] Polio is a life-threatening disease that can cause paralysis, poor muscle function that weakens the ability to breath, and brain problems.