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20807 Ensembl ENSG00000112658 ENSMUSG00000015605 UniProt P11831 Q9JM73 RefSeq (mRNA) NM_003131 NM_001292001 NM_020493 RefSeq (protein) NP_001278930 NP_003122 NP_003122.1 NP_065239 Location (UCSC) Chr 6: 43.17 – 43.18 Mb Chr 17: 46.86 – 46.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serum response factor, also known as SRF, is a transcription factor protein. Function Serum ...
The downstream target of Elk1 is the serum response element (SRE) of the c-fos proto-oncogene. [11] [12] To produce c-fos, a protein encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. [13] [14] MAPKs are the final effectors of signal transduction pathways that begin at the plasma membrane. [15]
Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. [5] [6] [7] Cavin-2 is highly expressed in a variety of human endothelial cells. [8] This gene has a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells.
The protein encoded by this gene is regulated by the actin cytoskeleton and is shuttled between the cytoplasm and the nucleus as a result of actin dynamics. [9] In the nucleus, it coactivates the transcription factor serum response factor, [10] a key regulator of smooth muscle cell differentiation, in an interaction mediated by its Basic domain.
SAP1a is a nuclear protein stimulating transcription via the c-fos serum response element, and additionally via an Ets binding site independently of the serum response factor. [1] Insulin activated the human INSIG2 promoter in a process mediated by phosphorylated SAP1a. [2] Sap1a is phosphorylated efficiently by ERKs but not by SAPK/JNKs. Serum ...
Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma , a monoclonal gammopathy of uncertain significance (MGUS), or further investigate a discrepancy ...
Serum total protein, also known as total protein, is a clinical chemistry parameter representing the concentration of protein in serum. [1] Serum contains many proteins including serum albumin, a variety of globulins, and many others. While it is possible to analyze these proteins individually, total protein is a relatively quick and ...
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids .