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Pre-cancer of the breast is a precancerous condition of the breast. It may eventually develop into breast cancer. There are two types: Ductal carcinoma in situ, the most common type of breast pre-cancer; Lobular carcinoma in situ, pre-cancer of the breast that is outside the milk ducts
About 20–30% of those who do not receive treatment develop breast cancer. [10] [11] DCIS is the most common type of pre-cancer in women. There is some disagreement on its status as cancer; some bodies include DCIS when calculating breast cancer statistics, while others do not. [12] [13]
Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer ...
A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [1] [2] [3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.
Carcinoma in situ (CIS) is a group of abnormal cells. [1] [2] While they are a form of neoplasm, [3] there is disagreement over whether CIS should be classified as cancer.This controversy also depends on the exact CIS in question (e.g., cervical, skin, breast).
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because of ...
Cancer stem cells in breast tumors were first discovered in 2003. [6] There are different theories exist on the origins of these cells. There are findings that indicates that normal cells undergo mutations which result in their transformation into BCSCs, [7] while there are also studies which concluded that these cells come from the misplacement of somatic stem cells de novo.
[3] [4] In addition, this cell line has a low expression of the Ki-67 proliferation marker, down regulation of claudin-3 and claudin-4, enrichment for markers associated with the epithelial-mesenchymal transition and the CD44+ CD24-/low phenotype associated with breast cancer stem cells and increased metastasis, [5] [6] [7] and is a mutant in ...