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In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
The simplest case of a normal distribution is known as the standard normal distribution or unit normal distribution. This is a special case when μ = 0 {\textstyle \mu =0} and σ 2 = 1 {\textstyle \sigma ^{2}=1} , and it is described by this probability density function (or density): φ ( z ) = e − z 2 2 2 π . {\displaystyle \varphi (z ...
Serum vancomycin levels may be monitored in an effort to reduce side effects, [27] but the value of such monitoring has been questioned. [28] Peak and trough levels are usually monitored, and for research purposes the area under the concentration curve is also sometimes used. [29] Toxicity is best monitored by looking at trough values. [29]
In statistics, the 68–95–99.7 rule, also known as the empirical rule, and sometimes abbreviated 3sr, is a shorthand used to remember the percentage of values that lie within an interval estimate in a normal distribution: approximately 68%, 95%, and 99.7% of the values lie within one, two, and three standard deviations of the mean, respectively.
The skew normal distribution; Student's t-distribution, useful for estimating unknown means of Gaussian populations. The noncentral t-distribution; The skew t distribution; The Champernowne distribution; The type-1 Gumbel distribution; The Tracy–Widom distribution; The Voigt distribution, or Voigt profile, is the convolution of a normal ...
It is possible to have variables X and Y which are individually normally distributed, but have a more complicated joint distribution. In that instance, X + Y may of course have a complicated, non-normal distribution. In some cases, this situation can be treated using copulas.
The shape of a distribution will fall somewhere in a continuum where a flat distribution might be considered central and where types of departure from this include: mounded (or unimodal), U-shaped, J-shaped, reverse-J shaped and multi-modal. [1] A bimodal distribution would have two high points rather than one. The shape of a distribution is ...
In probability and statistics, the truncated normal distribution is the probability distribution derived from that of a normally distributed random variable by bounding the random variable from either below or above (or both). The truncated normal distribution has wide applications in statistics and econometrics.