Search results
Results from the WOW.Com Content Network
Exon trapping or 'gene trapping' is a molecular biology technique that exploits the existence of the intron-exon splicing to find new genes. [13] The first exon of a 'trapped' gene splices into the exon that is contained in the insertional DNA .
Distinction between genome, exome, and transcriptome. The exome consists of all of the exons within the genome. In contrast, the trascriptome varies between cell types (e.g. neurons vs cardiac cells), only involving a portion of the exons that are actually transcribed into mRNA.
Exon trapping is a molecular biology technique to identify potential exons in a fragment of eukaryote DNA of unknown intron-exon structure. [1] This is done to determine if the fragment is part of an expressed gene .
Exome sequencing is especially effective in the study of rare Mendelian diseases, because it is an efficient way to identify the genetic variants in all of an individual's genes.
The CCDS dataset is an integral part of the GENCODE gene annotation project [11] and it is used as a standard for high-quality coding exon definition in various research fields, including clinical studies, large-scale epigenomic studies, exome projects and exon array design. [3]
Exon skipping is used to restore the reading frame within a gene. Genes are the genetic instructions for creating a protein, and are composed of introns and exons.Exons are the sections of DNA that contain the instruction set for generating a protein; they are interspersed with non-coding regions called introns.
Nearly half of all women have "dense breasts"—yet countless don't find out until later in life. Dense breasts have more fibrous and glandular tissue relative to fat tissue in the breast. Because ...
ESEs are clinically significant because synonymous point mutations previously thought to be silent mutations located in an ESEs can lead to exon skipping and the production of a non functioning protein. Disruption of an exon splicing enhancer in exon 3 of MLH1 gene is the cause of HNPCC (hereditary nonpolyposis colorectal cancer) in a Quebec ...