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It is still unknown whether or not these aggregates are a cause or a result of neurodegeneration. [ 9 ] autophagy–lysosome pathways: a form of programmed cell death (PCD), this becomes the favorable route when a protein is aggregate-prone meaning it is a poor proteasome substrate.
Retrogenesis is a medical hypothesis that just as the fetus goes through a process of neurodevelopment beginning with neurulation and ending with myelination, the brains of people with Alzheimer's disease go through a reverse neurodegeneration process starting with demyelination and death of axons (white matter) and ending with the death of ...
The causes listed are relatively immediate medical causes, but the ultimate cause of death might be described differently. For example, tobacco smoking often causes lung disease or cancer, and alcohol use disorder can cause liver failure or a motor vehicle accident.
Pantothenate kinase-associated neurodegeneration (PKAN), formerly called Hallervorden–Spatz syndrome, [1] is a genetic degenerative disease of the brain that can lead to parkinsonism, dystonia, dementia, and ultimately death. Neurodegeneration in PKAN is accompanied by an excess of iron that progressively builds up in the brain.
Secondary symptoms may also arise. It is possible that the initial iron accumulation will cause additional neuronal damage and neuronal death. [3] The damaged neurons may be replaced by other cells in an effort to reverse the neurodegeneration. These cells often have a higher iron content.
Dementia is currently the seventh leading cause of death worldwide and has 10 million new cases reported every year (approximately one every three seconds). [2] There is no known cure for dementia. Acetylcholinesterase inhibitors such as donepezil are often used and may be beneficial in mild to moderate disorder, but the overall benefit may be ...
The Orange County Sheriff’s Department confirmed to multiple outlets on Wednesday, November 15, that the teen’s cause of death was a narcotic overdose. TMZ was first to report the news.
Transneuronal degeneration is the death of neurons resulting from the disruption of input from or output to other nearby neurons. [1] It is an active excitotoxic process when a neuron is overstimulated by a neurotransmitter (most commonly glutamate) [2] causing the dysfunction of that neuron (either damaging it or killing it) which drives neighboring neurons into metabolic deficit, resulting ...