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Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy.
The potential of viruses as anti-cancer agents was first realised in the early twentieth century, although coordinated research efforts did not begin until the 1960s. [7] A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents. [8]
Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. [1] Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. It gained regulatory approval in 2005 from China ...
Cancer gene therapy was introduced in 1992/93 (Trojan et al. 1993). [167] The treatment of glioblastoma multiforme, the malignant brain tumor whose outcome is always fatal, was done using a vector expressing antisense IGF-I RNA (clinical trial approved by NIH protocol no.1602 24 November 1993, [168] and by the FDA in 1994). This therapy also ...
A total of 5.94 million deaths were prevented for those five disease types, according to an NCI press release. ... about what steps they may want to take to help prevent and screen for cancer ...
Adenoviruses can lead to tumors in rodent models but do not cause cancer in humans; however, they have been exploited as delivery vehicles in gene therapy for diseases such as cystic fibrosis and cancer. [15] Simian virus 40 (SV40), a polyomavirus, can cause tumors in rodent models but is not oncogenic in humans. [16]
CPU-Z is more comprehensive in virtually all areas compared to the tools provided in the Windows to identify various hardware components, and thus assists in identifying certain components without the need of opening the case; particularly the core revision and RAM clock rate. It also provides information on the system's GPU.
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