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Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [2] [8] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Deficiency isn't common, but can produce some scary side effects when it does happen. ... Pernicious anemia, or Addison's anemia, is an autoimmune disease which decreases red blood cell count ...
Vitamin B 12 was discovered as a result of pernicious anemia, an autoimmune disorder in which the blood has a lower than normal number of red blood cells, due to a deficiency of vitamin B 12. [ 5 ] [ 16 ] The ability to absorb the vitamin declines with age, especially in people over 60.
Pernicious anemia caused by loss of intrinsic factor cannot be prevented. [105] If there are other, reversible causes of low vitamin B 12 levels, the cause must be treated. [106] Vitamin B 12 deficiency anemia is usually easily treated by providing the necessary level of vitamin B 12 supplementation. [107]
Pernicious anemia is the most common cause of vitamin B 12 deficiency. [17] While it technically refers to anemia caused specifically by autoimmune deficiency of intrinsic factor, it is commonly used to refer to B 12-deficient anemia as a whole, regardless of cause.
In patients with pernicious anemia or with deficiency due to impaired absorption, less than 10% of the radiolabeled vitamin B 12 is detected. The normal test will result in a higher amount of the radiolabeled cobalamin in the urine because it would have been absorbed by the intestinal epithelium, but passed into the urine because all hepatic ...
Subacute combined degeneration of spinal cord, also known as myelosis funiculus, or funicular myelosis, [1] also Lichtheim's disease, [2] [3] and Putnam-Dana syndrome, [4] refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B 12 deficiency (most common).
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