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Elastic tissue loss, vascular and connective tissue degradation, and skin and cartilage thinning are all brought on by aging. [6] The onset of CNCH symptoms may be related to the cartilage's increased susceptibility to pressure damage as it ages and loses some of its flexibility. Additionally, older adults typically move less while they sleep ...
Actinic elastosis, also known as solar elastosis, is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, [2] or in the conjunctiva of the eye, [3] which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging.
Cutis laxa may be caused by mutations in the genes: ELN, [8] ATP6V0A2, [9] ATP7A, [10] FBLN4, [11] FBLN5, [12] and PYCR1. [13] A related neurocutaneous syndrome may be caused by mutations in the gene ALDH18A1 (P5CS). [14] Cutis laxa may also be seen in association with inherited connective tissue disorders such as Ehlers–Danlos syndromes.
According to histopathology, there may be more localized wavy fibers in the dermis, which are visible when elastic staining separates normal from hypertrophic collagen bundles. [3] There may be fragmentation or aggregation of the elastic fibers in the deep and upper dermis. [ 2 ]
Sarcopenia (ICD-10-CM code M62.84 [1]) is a type of muscle loss that occurs with aging and/or immobility. It is characterized by the degenerative loss of skeletal muscle mass, quality, and strength. The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors.
The latter two conditions are jointly referred to as tissue loss, reflecting the development of surface damage to the limb tissue due to the most severe stage of ischemia. Compared to the other manifestation of PAD, intermittent claudication , CLI has a negative prognosis within a year after the initial diagnosis, with 1-year amputation rates ...
Pseudoxanthoma elasticum (PXE) is a genetic disease that causes mineralization of elastic fibers in some tissues. The most common problems arise in the skin and eyes, and later in blood vessels in the form of premature atherosclerosis.
[10] [11] Surgery can help alleviate skin contractures in the form of skin grafts and removal of hypertrophic scars. [8] [6] For hypertrophic scars, timing is important when considering surgery, as over time scars will mature and may show decreased contractures along with flattening, softening, and repigmentation without surgical intervention. [8]