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Elastic tissue loss, vascular and connective tissue degradation, and skin and cartilage thinning are all brought on by aging. [6] The onset of CNCH symptoms may be related to the cartilage's increased susceptibility to pressure damage as it ages and loses some of its flexibility. Additionally, older adults typically move less while they sleep ...
Actinic elastosis, also known as solar elastosis, is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, [2] or in the conjunctiva of the eye, [3] which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging.
Connective tissue disease, also known as connective tissue disorder, or collagen vascular diseases, refers to any disorder that affects the connective tissue. [1] The body's structures are held together by connective tissues, consisting of two distinct proteins : elastin and collagen .
Collagen loss is the gradual decrease of levels of collagen in the body. Collagen is the main structural protein found in the body's various connective tissues (skin, bones, tendons, etc.) where it contributes to much of their strength and elasticity.
Angioid streaks, also called Knapp streaks or Knapp striae, are small breaks in Bruch's membrane, an elastic tissue containing membrane of the retina that may become calcified and crack. [2] Up to 50% of angioid streak cases are idiopathic. [3] It may occur secondary to blunt trauma, or it may be associated with many systemic diseases. [4]
As of 2024, there is no treatment for cutis laxa. Procedures aimed at mitigating symptoms and identifying subsequent conditions are often advised. No pharmacological agent has been able to stop the progression of the disease. [15] However, cosmetic surgeries are potentially an option as cutis laxa does not generally involve vascular fragility. [15]
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The latter two conditions are jointly referred to as tissue loss, reflecting the development of surface damage to the limb tissue due to the most severe stage of ischemia. Compared to the other manifestation of PAD, intermittent claudication , CLI has a negative prognosis within a year after the initial diagnosis, with 1-year amputation rates ...