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Intractable pain, also called intractable pain syndrome (IPS), is a severe, constant, relentless, and debilitating pain that is not curable by any known means and which causes a house-bound or bed-bound state and early death if not adequately treated, usually with opioids and/or interventional procedures. It is not relieved by ordinary medical ...
In these situations of hypertensive emergency, rapid reduction of the blood pressure is mandated to stop ongoing organ damage. [4] In contrast there is no evidence that blood pressure needs to be lowered rapidly in hypertensive urgencies , where there is no evidence of target organ damage; over-aggressive reduction of blood pressure is not ...
[3] [4] Chronic pain is considered a syndrome because of the associated symptoms that develop in those experiencing this disorder. [5] Chronic pain affects approximately 20% of people worldwide and accounts for 15–20% of visits to a physician. [3] Pain can be categorized according to its location, cause, or the anatomical system which it affects.
The effect of treatment of blood pressure between 130/80 mmHg and 160/100 mmHg is less clear, with some reviews finding benefit [6] [16] [17] and others finding unclear benefit. [18] [19] [20] High blood pressure affects 33% of the population globally. [9] About half of all people with high blood pressure do not know that they have it. [9]
A diagram explaining factors affecting arterial pressure. Pathophysiology is a study which explains the function of the body as it relates to diseases and conditions. The pathophysiology of hypertension is an area which attempts to explain mechanistically the causes of hypertension, which is a chronic disease characterized by elevation of blood pressure.
Various factors cause the formation of chronic pain, which can be neurogenic (gene-dependent), nociceptive, neuropathic, psychological or unknown. Some diseases such as diabetes (high blood sugar), shingles (some viral diseases), phantom limb pain, hypertension and stroke also play a role in the formation
Hypertension or high blood pressure affects at least 26.4% of the world's population. [15] Hypertensive heart disease is only one of several diseases attributable to high blood pressure. Other diseases caused by high blood pressure include ischemic heart disease, cancer, stroke, peripheral arterial disease, aneurysms and kidney disease.
Complex regional pain syndrome is a multifactorial disorder with clinical features of neurogenic inflammation (inflammation mediated by nerve cells), nociceptive sensitisation (which causes extreme sensitivity or allodynia), vasomotor dysfunction (blood flow problems which cause swelling and discolouration) and maladaptive neuroplasticity ...
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