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Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Hemosiderin image of a kidney viewed under a microscope. The brown areas represent hemosiderin. Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin ...
Hemosiderin collects in the skin and is slowly removed after bruising; hemosiderin may remain in some conditions such as stasis dermatitis. Hemosiderin in the kidneys has been associated with marked hemolysis and a rare blood disorder called paroxysmal nocturnal hemoglobinuria. Hemosiderin may deposit in diseases associated with iron overload.
Postinflammatory hyperpigmentation (PIH) is a skin condition characterized by the darkening of the skin (hyperpigmentation) following an inflammatory injury, such as acne, dermatitis, infectious disease, or trauma. Less frequently, it may occur as a complication of a medical procedure performed on the skin. It is a common cause of skin ...
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Fat necrosis in the breast occurs around 0.6%, this represents 2.75% of lesions that end up being benign. However, 0.8% of fat necrosis occurs from tumors of the breast, 1–9% occurs in breast reduction surgery. Individuals that are high risk include women around the age of 50yrs along with pendulous breasts. [8]
Immunohistochemical staining is used to establish receptor status, and the presence or absence of pertinent genes is determined by DNA testing. This article will discuss the features specific to invasive carcinoma NST. More general and complete discussions can be found in articles on breast cancer screening and breast cancer classification.
Transfusional hemosiderosis is a potential side effect of frequent blood transfusions. [2] These may be given for a number of conditions, including: thalassemia. sickle cell disease. [3] leukemia. aplastic anemia. myelodysplastic syndrome.