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A zeitgeber (/ ˈ (t) s aɪ t ɡ eɪ b ər, ˈ z aɪ t-/ (T)SYTE-gay-bər, ZYTE-, German: [ˈtsaɪtˌɡeːbɐ]) is any external or environmental cue that entrains or synchronizes an organism's biological rhythms, usually naturally occurring and serving to entrain to the Earth's 24-hour light/dark and 12-month cycles.
A circadian rhythm (/ s ər ˈ k eɪ d i ə n /), or circadian cycle, is a natural oscillation that repeats roughly every 24 hours.Circadian rhythms can refer to any process that originates within an organism (i.e., endogenous) and responds to the environment (is entrained by the environment).
Biological rhythms are endogenous; they persist even in the absence of environmental cues as they are driven by an internal mechanism, most notably the circadian clock. Of the several possible cues (known as zeitgebers, German for 'time-givers') that can contribute to entrainment of the circadian clock, light has the greatest impact.
Endogenous: Growing or working from within an organism; intrinsic. Entrainment : The process an organism undergoes when synchronizing endogenous rhythms to a Zeitgeber. Free-Running Period (FRP) : The length of time it takes for an organism's endogenous rhythm to repeat without Zeitgebers in constant conditions (LL or DD).
The hypothesis states that each set of these genes would be sufficient to produce endogenous oscillation in cell function; however, each gene set responds differently to light and temporal cues. The per1/cry1 oscillator (morning oscillator) is energized by light and tracks dawn.
An artificial cardiac pacemaker (or artificial pacemaker, so as not to be confused with the natural cardiac pacemaker) or just pacemaker is an implanted medical device that generates electrical impulses delivered by electrodes to the chambers of the heart either the upper atria, or lower ventricles to cause the targeted chambers to contract and ...
The cardiac pacemaker is the heart's natural rhythm generator. It employs pacemaker cells that generate electrical impulses, known as cardiac action potentials . These potentials cause the cardiac muscle to contract, and the rate of which these muscles contract determines the heart rate .
In pacemaker cells (e.g. sinoatrial node cells), however, the increase in membrane voltage is mainly due to activation of L-type calcium channels. These channels are also activated by an increase in voltage, however this time it is either due to the pacemaker potential (phase 4) or an oncoming action potential. The L-type calcium channels are ...