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Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur. [23]
Changes in skin: This often looks like noticeable dryness, flaky, or scaly skin, especially around the eyes, nose, and mouth. Changes in nails: You may start to notice your nails becoming more ...
Discover what this essential B vitamin can do for your body and whether you need more in your diet.
Biotin deficiency is very uncommon, but experiencing it can cause an array of side effects, including: hair thinning or loss, brittle nails, a red scaly rash (around the eyes, nose, and mouth), a ...
Signs and symptoms of a biotinidase deficiency (BTD) can appear several days after birth. These include seizures, hypotonia and muscle/limb weakness, ataxia, paresis, hearing loss, optic atrophy, skin rashes (including seborrheic dermatitis and psoriasis), and alopecia. If left untreated, the disorder can rapidly lead to coma and death.
Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face. [2] [4] Aside from inadequate dietary intake (rare), deficiency of biotin can be caused by a genetic disorder that affects biotin metabolism. The most common among these is biotinidase deficiency.
Some vitamin deficiencies, such as a biotin deficiency and iron deficiency, can lead to hair loss or unhealthy hair. (Related: 12 Best Vitamins for Hair Growth ) Chris6 / iStock
The signs and symptoms of holocarboxylase synthetase deficiency typically appear within the first few months of life, but the age of onset varies. Affected infants often have immunodeficiency diseases, difficulty feeding, breathing problems, a skin rash, hair loss , and a lack of energy . Immediate treatment and lifelong management (using ...