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Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.
Specialty professional organizations recommend that people take the lowest effective PPI dose to achieve the desired therapeutic result when used to treat gastroesophageal reflux disease long-term. [ 20 ] [ 21 ] [ 22 ] In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC ...
Omeprazole was the first PPI on the market, in 1988. It is a 1:1 racemate drug with a backbone structure of timoprazole, but substituted with two methoxy and two methyl groups. One of the methoxy group is at position 6 of the bensoimidazole and the other at position 4 of the pyridine and the methyl groups are at position 3 and 5 of the pyridine.
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One of the children, who was born at 28 weeks gestation with respiratory complications and had a fundoplication for gastroesophageal reflux and failure to thrive was prescribed domperidone. An advocate for the mother suggested the child may have had neuroleptic malignant syndrome as a side effect of domperidone due to the drug crossing the ...
The seventh drop fell at approximately 4:45 p.m. on 3 July 1988, while the experiment was on display at Brisbane's World Expo 88. However, apparently no one witnessed the drop fall itself; [5] Professor Mainstone had stepped out to get a drink at the moment it occurred. [1]
Crokinole boards are typically octagonal or round in shape. The wooden discs are roughly checker-sized, slightly smaller in diameter than the board's central hole, and typically have one side slightly concave and one side slightly convex, mainly due to the inherent features of wood, more than a planned design. Alternatively, the game may be ...
Jerry purchased the liquor and cigarettes. They opened at 7 a.m. and didn’t leave until midnight, even opening on Christmas morning, when Evart’s only grocery store was closed. Everyone in town passed through the Corner Store—factory workers, lawyers, bankers—and if Jerry didn’t know a customer by name, he knew him by his order.