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Photosensitive drug reaction secondary to medications may cause phototoxic, photoallergic, and lichenoid reactions, and photodistributed telangiectasias, as well as pseudoporphyria. [1]: 121 Drugs involved include naproxen and doxycycline.
Doxycycline can cause gastrointestinal upset. [70] [71] Oral doxycycline can cause pill esophagitis, particularly when it is swallowed without adequate fluid, or by persons with difficulty swallowing or impaired mobility. [72] Doxycycline is less likely than other antibiotic drugs to cause Clostridioides difficile colitis. [73]
These enzymes dissolve the basement membrane and fibrils of the hemidesmosomes, which can lead to the separation of the epithelial layer. Treatment with oral tetracycline antibiotics (such as doxycycline or oxytetracycline ) together with a topical corticosteroid (such as prednisolone ), reduce MMP activity and may rapidly resolve and prevent ...
Phototoxicity, also called photoirritation, is a chemically induced skin irritation, requiring light, that does not involve the immune system. [1] It is a type of photosensitivity. [1] [2] The skin response resembles an exaggerated sunburn.
Sunlight, especially its ultraviolet radiation component, can cause increased or additional types of damage in predisposed individuals, such as those taking certain phototoxic drugs, or those with certain conditions associated with photosensitivity, including: Psoriasis [5] Atopic eczema [5] Mastocytosis; Mast cell activation syndrome ...
It increases the risk of sunburn under exposure to light from the sun or other sources. This may be of particular importance for those intending to take on vacations long-term doxycycline as a malaria prophylaxis. They may cause stomach or bowel upsets, and, on rare occasions, allergic reactions.
Other studies report a good efficacy of 50 mg once a day in less severe cases. A formulation of 40 mg with a delayed release for long-term therapy can also be used. Side effects of treating ocular rosacea with doxycycline include nausea, vomiting, photosensitivity and headache, which may lead to premature discontinuation of treatment.
Many medications and conditions can cause sun sensitivity, including: Sulfa used in some drugs, among them some antibiotics, diuretics, COX-2 inhibitors, and diabetes drugs. [1] Psoralens, coal tars, photo-active dyes (eosin, acridine orange) Musk ambrette, methylcoumarin, lemon oil (may be present in fragrances) PABA (found in sunscreens)