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The evidence overall supports the effectiveness of bupropion over placebo for the treatment of depression. [41] [18] [42] Some peer-reviewed studies suggest the quality of evidence is low. [42] [18] Some meta-analyses report that bupropion has an at-most small effect size for depression. [43] [44] [42] [45] One meta-analysis reported a large ...
Wellbutrin and other antidepressants may cause an increase in risk of suicide in young adults. If you start to feel suicidal after using Wellbutrin, it’s important to seek professional medical ...
SSRIs (fluoxetine in particular) are preferred over other antidepressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials. Long-term efficacy remains poorly characterized. Bupropion is not recommended for the treatment of eating disorders, due to an increased risk of seizure. [61]
In rare instances, bupropion can increase your risk for seizures. If you have a history of seizures, be sure to mention it to your healthcare professional. Viktoria Korobova/istockphoto
Bupropion, on the other hand, is one of the few antidepressants that don’t cause these common side effects, and some research shows it can have the opposite effect — increasing your libido.
The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Antidepressant efficacy of dextromethorphan/bupropion (Auvelity) versus placebo in the GEMINI clinical trial. [1] [3] [4] [5] The scores shown are the mean total depression scores on the MADRS over 6 weeks. Only 124/156 patients completed 6 weeks of Auvelity while 150/162 patients completed 6 weeks of placebo, consistent with a high rate of ...