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[citation needed] For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual. [7] [8] Equivalent doses of benzodiazepines differ as much as 20 fold. [9] [10] [11]
A clinically relevant lorazepam dose will normally be effective for six to 12 hours, making it unsuitable for regular once-daily administration, so it is usually prescribed as two to four daily doses when taken regularly, but this may be extended to five or six, especially in the case of elderly people who could not handle large doses at once.
Adverse effects on cognition can be mistaken for the effects of old age. The benefits of withdrawal include improved cognition, alertness, mobility, reduced risk of incontinence, and a reduced risk of falls and fractures. The success of gradual-tapering benzodiazepines is as great in the elderly as in younger people.
In 1989, in a 4- to 6-year follow-up study of 30 inpatient people who used benzodiazepines non-medically, Neuropsychological function was found to be permanently affected in some people with long-term high dose non-medical use of benzodiazepines. Brain damage similar to alcoholic brain damage was observed.
The CDC recommends three flu vaccines for people 65 and older: the Fluzone High-Dose inactivated flu ... meningitis and blood infections, and older people (and children under 2) are at the ...
Lorazepam is preferred to other benzodiazepines and zolpidem due to its longer duration of action. [4] An initial therapeutic effect typically occurs within 10–30 minutes of IV administration lorazepam at doses between 2–4 mg. [5] [4] Higher doses may be used in patients who are unresponsive, to minimise the chance of a false negative ...
A clinical trial in elderly people dependent on benzodiazepine hypnotics showed that the addition of CBT to a gradual benzodiazepine reduction program increased the success rate of discontinuing benzodiazepine hypnotic drugs from 38% to 77% and at the 12-month follow-up from 24% to 70%.
The CDC’s new COVID-19 vaccine recommendations suggest a second dose of the updated COVID-19 vaccine for people who are 65+, as well as those who are moderately or severely immunocompromised ...