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Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, ...
It contains leuprorelin as the acetate, a gonadotropin-releasing hormone agonist, and norethisterone acetate, a progestin. [1] The leuprorelin is given by intramuscular injection and the norethisterone acetate is taken by mouth. [1] The co-packaged medication was approved for medical use in the United States in December 2012. [2]
A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
A GnRH modulator, or GnRH receptor modulator, also known as an LHRH modulator or LHRH receptor modulator, is a type of medication which modulates the GnRH receptor, the biological target of the hypothalamic hormone gonadotropin-releasing hormone (GnRH; also known as luteinizing-releasing hormone, or LHRH).
GnRH analogues include GnRH agonists like leuprorelin or goserelin and GnRH antagonists like cetrorelix. [31] They are powerful antigonadotropins and work by abolishing the GnRH -induced secretion of gonadotropins, in turn ceasing gonadal production of sex hormones. [ 31 ]
Testosterone levels in the long-term androgen deprivation therapy of men with prostate cancer by different GnRH agonists administered at 3 month intervals (goserelin, triptorelin and leuprorelin). Dotted line is the threshold for the castrate range. [27]
German/Swiss company Sandoz makes leuprorelin (Leuprorelin Acetate, Lucrin, Eligard). [65] In Japan, Takeda Pharmaceutical Company and Astellas Pharma create leuprorelin (Lupron Depot) and goserelin (Zoladex). [60] [66] Indian company Sun Pharmaceutical Industries mainly produces leuprolide acetate generic injectables. [67] AbbVie is also a ...
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
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