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HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis. It was introduced in 1978 and shows resistance against racemization. It was introduced in 1978 and shows resistance against racemization.
Gastric Pentadecapeptide BPC-157 (also known as PL 14736, Body Protection Compound 157, or Bepecin) is a fifteen amino acid long oligopeptide that was discovered during research on human gastric juice. [1] The amino acid sequence is as follows: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. [2]
Custom peptide synthesis provides synthetic peptides as valuable tools to biomedical laboratories. Synthetic oligopeptides are used extensively in research for structure-function analysis (for example to study protein-protein interfaces), for the development of binding assays, the study of receptor agonist/antagonists or as immunogens for the ...
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From this came the earliest antibacterial sulfa drugs, phenolic compounds made famous by Joseph Lister, and plastics. During the 1800s, pharmacists specialized in the raising, preparation and compounding of crude drugs. Crude drugs, like opium, are from natural sources and usually contain several chemical compounds.
The solid phase now bears a dipeptide. This cycle is repeated to form the desired peptide chain. After all reactions are complete, the synthesised peptide is cleaved from the bead. The protecting groups for the amino groups mostly used in the peptide synthesis are 9-fluorenylmethyloxycarbonyl group and t-butyloxycarbonyl . A number of amino ...
BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) is a reagent commonly used for the synthesis of amides from carboxylic acids and amines in peptide synthesis. [ 1 ] [ 2 ] It can be prepared from 1-hydroxybenzotriazole and a chlorophosphonium reagent under basic conditions. [ 3 ]
Hydroxybenzotriazole (abbreviated HOBt) is an organic compound that is a derivative of benzotriazole.It is a white crystalline powder, which as a commercial product contains some water (~11.7% wt as the HOBt monohydrate crystal).
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