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Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.
The LiMAx test is an innovative enzymatic liver function test. 13 C-methacetin, a selective metabolite of the liver specific cytochrome P450 1A2 is administered intravenously. Via the bloodstream the drug is transported to the liver and immediately metabolized to paracetamol and ultimately to 13 CO 2 (Fig. 1), which is in turn transported via ...
The more drug there is in the sample, the more free enzyme there will be, and the increased enzyme activity causes a change in color. [ 2 ] : 70 Determination of drug levels in serum is particularly important when the difference in the concentrations needed to produce a therapeutic effect and adverse side reactions (the therapeutic window ) is ...
Bromsulfthalein (also known as bromsulphthalein, bromosulfophthalein, and BSP) is a phthalein dye used in liver function tests. Determining the rate of removal of the dye from the blood stream gives a measure of liver function. [1] The mechanism by which the liver detoxifies BSP is to attach it to glutathione which is the body’s master ...
Pages in category "Liver function tests" The following 7 pages are in this category, out of 7 total. This list may not reflect recent changes. ...
A complete blood test can help distinguish intrinsic liver disease from extrahepatic bile-duct obstruction. [19] An ultrasound of the liver can reliably detect a dilated biliary-duct system, [20] it can also detect the characteristics of a cirrhotic liver. [21] Computerized tomography (CT) can give accurate anatomical information for a complete ...
In patients with deranged liver function tests, ultrasound may show increased liver size (hepatomegaly), increased reflectiveness (which might, for example, indicate cholestasis), gallbladder or bile duct diseases, or a tumor in the liver. Ultrasonography of liver tumors involves two stages: detection and characterization.
The function and role of quiescent hepatic stellate cells is unclear. Recent evidence suggests a role as a liver-resident antigen-presenting cell, presenting lipid antigens to and stimulating proliferation of NKT cells. [7] When the liver is damaged, stellate cells can change into an activated state.