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Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and N-acetyl-D-glucosamine, linked via alternating β-(1→4) and β-(1→3) glycosidic bonds. Hyaluronic acid can be 25,000 disaccharide repeats in length. Polymers of hyaluronic acid can range in size from 5,000 to 20,000,000 Da in vivo.
Chain elongation, beginning from the GlcNAc primer, occurs with sequential addition of alternating UDP-GlcA and UDP-GlcNAc units to the reducing end of the growing chain. [19] Diagram of the mechanism of hyaluronan synthase. In each iteration of chain elongation, one active site domain is occupied by the existing UDP-hyaluronan chain.
15117 Ensembl ENSG00000170961 ENSMUSG00000022367 UniProt Q92819 P70312 RefSeq (mRNA) NM_005328 NM_008216 RefSeq (protein) NP_005319 NP_032242 Location (UCSC) Chr 8: 121.61 – 121.64 Mb Chr 15: 56.53 – 56.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene. Hyaluronan or hyaluronic acid is a high molecular ...
Materials may swell, collapse, or change depending on the pH of their environment. This behavior is exhibited due to the presence of certain functional groups in the polymer chain. pH-sensitive materials can be either acidic or basic, responding to either basic or acidic pH values. These polymers can be designed with many different ...
Plus, it features multiple weights of hyaluronic acid for a refreshing burst of hydration. Key ingredients: Poly-peptide complex, marine bamboo, hyaluronic acid Skin type: Normal, dry
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds.
Though it's best known in the world of skincare, hyaluronic acid is a superstar ingredient in many hydrating hair products. Here, experts break down its benefits, side effects, and how to use it.
Hyaluronic acid binds cells together, lubricates joints, and helps maintain the shape of the eyeballs. [19] The viscoelasticity of hyaluronic acid makes it ideal for lubricating joints and surfaces that move along each other, such as cartilage. A solution of hyaluronic acid under low shear stress has a much higher viscosity than while under ...
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