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Trk, initially identified in a colon carcinoma, is frequently (25%) activated in thyroid papillary carcinomas. [5] The oncogene was generated by a mutation in chromosome 1 that resulted in the fusion of the first seven exons of tropomyosin to the transmembrane and cytoplasmic domains of the then-unknown TrkA receptor. [ 4 ]
18211 Ensembl ENSG00000198400 ENSMUSG00000028072 UniProt P04629 Q3UFB7 RefSeq (mRNA) NM_002529 NM_001007792 NM_001012331 NM_001033124 RefSeq (protein) NP_001007793 NP_001012331 NP_002520 NP_001028296 Location (UCSC) Chr 1: 156.82 – 156.88 Mb Chr 3: 87.69 – 87.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve ...
Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8]
Tropomyosin receptor kinases, also known as neurotrophic tyrosine kinase receptors (Trk) play an essential role in the biology of neurons by mediating Neurotrophin-activated signaling. There are three transmembrane receptors TrkA , TrkB and TrkC (encoded by the genes NTRK1, NTRK2 and NTRK3 respectively) make up the Trk receptor family. [ 11 ]
The company will increase hourly pay for its top of the scale employees over the next three years, with the pay rising by $1 to $30.20 in the first year and an extra $1 each in the subsequent two ...
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