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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
CB 2 (3.5x) JWH-358 [14] Dibenzopyran: 1243 ± 266: 52 ± 3: CB 2 (24x) JWH-359: Dibenzopyran: 2918 ± 450: 13.0 ± 0.2 CB 2 (220x) JWH-360 [14] Dibenzopyran: 2449 ± 606: 160 ± 8: CB 2 (15x) JWH-361 [14] Dibenzopyran: 63 ± 3: 2.7 ± 0.1: CB 2 (23x) JWH-362 [14] Dibenzopyran: 127 ± 8 34 ± 5: CB 2 (3.7x) JWH-363 [13] Naphthoylpyrrole: 245 ± ...
THJ-018 (SGT-17) is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug. [1] [2] Pharmacology
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018 .
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [135] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. [3] With a K i of 1.2nM it is fairly selective for the CB 1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB 2 (12.4nM). [ 4 ]
FUB-JWH-018 (also known as FUB-018) is a naphthoylindole-based synthetic cannabinoid, representing a molecular hybrid of JWH-018 and AB-FUBICA or ADB-FUBICA. [1] [2]
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