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By 2007, the ketogenic diet was available from around 75 centres in 45 countries, and less restrictive variants, such as the modified Atkins diet, were in use, particularly among older children and adults. The ketogenic diet was also under investigation for the treatment of a wide variety of disorders other than epilepsy. [1]
After one year on the ketogenic diet, the success rate (seizure reduction over 50%) is between 30 and 50% and the dropout rate is around 45%. [32] [33] Although the ketogenic diet can be very effective, some families report that it's not compatible with daily life given its restrictive nature. It can be especially difficult for adolescents to ...
A few cases have shown that patients were able to lessen their attacks with a high carbohydrate snack. A new approach to managing PED is the ketogenic diet, which alters the primary cerebral energy metabolism from glucose to ketone bodies. Reports have shown that the ketonic diet protects against seizures in epilepsy. [2]
The ketogenic diet was a popular treatment for pediatric epilepsy prior to the discovery of anti seizure medications. [38] The Modified Atkins Diet (MAD) is a low carbohydrate diet which has caused reductions in seizure frequency and severity, though not as effectively as the ketogenic diet. [26]
Ketogenic diet may be effective as second-line therapy for treatment-resistant cases. Neurosurgery may be indicated in certain cases. [2] [7] Epileptic spasms are commonly classified as symptomatic when a potential cause can be identified, or as cryptogenic if not (though these designations are used inconsistently). [2]
Once diagnosed, a medically supervised ketogenic diet is usually recommended as it can help to control seizures. [21] The ketogentic diet is the current standard of care treatment, with 80% of patients having >90% seizure reduction [13] and improving some movement disorders in approximately two thirds of GLUT1 deficiency patients. [18]
The ketogenic diet may also influence neurotransmitters like dopamine and serotonin, which regulate mood, and the gut microbiome, which affects behavior and stress response, Sawhne explained.
A ketogenic diet is a diet that causes ketosis, a state in which there is an increased amount of ketones in the body. Adopting and maintaining rigid diet may be difficult for some families. Short-term ketogenic diet might be associated with nonsignificant decreases in frequency of parent-reported seizures in children with LGS. [35]