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Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...
The study found that increased levels of both amyloid-beta and tau proteins in the brain may lead to changed brain activity before the cognitive symptoms of Alzheimer’s disease appear. Focusing ...
New research shows that glial cells play an important role in producing amyloid beta, a protein linked to Alzheimer’s disease. The study, undertaken by scientists at the Max Planck Institute ...
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...
The causes of Alzheimer's disease remain poorly understood. [16] There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. [17] [18] Other risk factors include a history of head injury, clinical depression, and high blood pressure. [1]
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
Alzheimer's disease (); Parkinson's disease (alpha-synuclein); Huntington's disease (huntingtin protein); Transmissible spongiform encephalopathies caused by prion protein (PrP) were sometimes classed as amyloidoses, as one of the four pathological features in diseased tissue is the presence of amyloid plaques.
“There are many people with pathological markers of Alzheimer’s disease without Alzheimer’s symptoms. Beta-amyloid, the pathological marker of Alzheimer’s disease, can start to accumulate ...
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