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To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. [2] The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). [3]
Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [24] APP is produced by many types of cell in the body, but it is especially abundant in neurons .
An instruction set architecture (ISA) is an abstract model of a computer, also referred to as computer architecture.A realization of an ISA is called an implementation.An ISA permits multiple implementations that may vary in performance, physical size, and monetary cost (among other things); because the ISA serves as the interface between software and hardware.
Amyloid deposits in tissue can cause enlargement of structures. Twenty percent of people with AL amyloidosis have an enlarged tongue, that can lead to obstructive sleep apnea, difficulty swallowing, and altered taste. [11] Tongue enlargement does not occur in ATTR or AA amyloidosis. [10] Deposition of amyloid in the throat can cause hoarseness ...
The first documented computer architecture was in the correspondence between Charles Babbage and Ada Lovelace, describing the analytical engine.While building the computer Z1 in 1936, Konrad Zuse described in two patent applications for his future projects that machine instructions could be stored in the same storage used for data, i.e., the stored-program concept.
Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis. [1] The disease is caused when a person's antibody -producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains .
Amyloid beta is commonly thought to be intrinsically unstructured, meaning that in solution it does not acquire a unique tertiary fold but rather populates a set of structures. As such, it cannot be crystallized and most structural knowledge on amyloid beta comes from NMR and molecular dynamics .
In computer engineering, an orthogonal instruction set is an instruction set architecture where all instruction types can use all addressing modes.It is "orthogonal" in the sense that the instruction type and the addressing mode may vary independently.