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Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone . [ 9 ]
Sorbitan monopalmitate (SMP) is a food additive, [2] permitted by the EU. It is entry E495 in the E number list of permitted food additives. [ 3 ] It is also known under the trade name Span 40.
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Polysorbate 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself. Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry. Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies. [5]
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Sorbitan is produced by the dehydration of sorbitol and is an intermediate in the conversion of sorbitol to isosorbide.The dehydration reaction usually produces sorbitan as a mixture of five- and six-membered cyclic ethers (1,4-anhydrosorbitol, 1,5-anhydrosorbitol and 1,4,3,6-dianhydrosorbitol) [3] with the five-membered 1,4-anhydrosorbitol form being the dominant product.