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Mosunetuzumab, sold under the brand name Lunsumio, is a monoclonal antibody used for the treatment of follicular lymphoma. [2] [3] [5] It bispecifically binds CD20 and CD3 to engage T-cells. [2] [3] It was developed by Genentech. [6] The most common adverse reactions (≥20%) include cytokine release syndrome, fatigue, rash, pyrexia, and headache.
Obinutuzumab has two black box warnings: hepatitis B reactivation and progressive multifocal leukoencephalopathy. [7] [5]In the clinical trial of obinutuzumab in combination with chlorambucil, participants experienced infusion reactions (69%; 21% grade 3/4), neutropenia (40%; 34% grade 3/4), thrombocytopenia (15%; 11% grade 3/4), anemia (12%), and pyrexia and cough (10% each).
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Revumenib, sold under the brand name Revuforj, is an anti-cancer medication used for the treatment of acute leukemias harboring lysine methyltransferase 2A gene (KMT2A) rearrangements. [1]
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The poll showed that 83% believe a president is required to follow the court’s ruling if it ruled against the president while 87% believe the court can review laws passed by Congress to ...
The US Food and Drug Administration (FDA) granted the application for moxetumomab pasudotox fast track, priority review, and orphan drug designations. [4] [17] The FDA granted the approval of a Biologics License Application for Lumoxiti to AstraZeneca Pharmaceuticals. [4] This was subsequently transferred to Innate Pharma in March 2020. [18]