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The gene fusion produces a chimeric protein segment from which a new antigenic peptide can be derived. The recognition of mutation-induced antigens on tumors by T cells is only one aspect of a more general phenomenon which can rightly be named: T cell immunosurveillance of the integrity of the genome.
Cross-presentation is the ability of certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8 + T cells into activated ...
Antigen processing and presentation in MHC-I pathway. Cytotoxic T cells (also known as T c, killer T cell, or cytotoxic T-lymphocyte (CTL)) express CD8 co-receptors and are a population of T cells that are specialized for inducing programmed cell death of other cells.
Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells.. A cytotoxic T cell (also known as T C, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8 + T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or ...
Studies of a tapasin-deficient cell line and from mice bearing a disrupted tapasin gene, the short-lived complex of class I molecules. [clarification needed] Tapasin and TAP are very important for the stabilization of the class I molecules and also for the optimization of the peptide presented to cytotoxic T cells. [7]
The α 3 domain is plasma membrane-spanning and interacts with the CD8 co-receptor of T-cells. The α 3-CD8 interaction holds the MHC I molecule in place while the T cell receptor (TCR) on the surface of the cytotoxic T cell binds its α 1-α 2 heterodimer ligand, and checks the coupled
Complementarity-determining regions (CDRs) are polypeptide segments of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively. CDRs are where these molecules bind to their specific antigen and their structure/sequence determines the binding activity of the respective antibody.
helper T lymphocyte having captured antigenic peptide-MHC complexes are involved in a negative regulatory feed-back loop leading to their inactivation [10] dendritic cells stripped of antigenic peptide-MHC complexes by T cells through trogocytosis contribute to affinity maturation of T cell response by selecting high-affinity T cell [11]