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Trimethyl phosphate is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds. [2] The method is complementary to the traditional Eschweiler-Clarke reaction in cases where formaldehyde engages in side reactions.
The general formula of a phosphoric acid is H n+2−2x P n O 3n+1−x, where n is the number of phosphorus atoms and x is the number of fundamental cycles in the molecule's structure, between 0 and n + 2 / 2 . Pyrophosphate anion. Trimethyl orthophosphate.
In organic chemistry, phosphate or orthophosphate is an organophosphate, an ester of orthophosphoric acid of the form PO 4 RR′R″ where one or more hydrogen atoms are replaced by organic groups. An example is trimethyl phosphate, (CH 3) 3 PO 4. The term also refers to the trivalent functional group OP(O-) 3 in such esters.
For example, the formula of methyl phosphate is CH 3-H 2 PO 4, dimethyl phosphate – (CH 3) 2 HPO 4 and trimethyl phosphate – (CH 3) 3 PO 4. Alkyl phosphates are widely distributed in nature, and form the basis of most biological processes. For example, high energy metabolites such as ATP and PEP are alkyl phosphates, as are nucleic acids ...
3,4,5-Trimethoxybenzaldehyde can be used as an intermediate in the synthesis of some pharmaceutical drugs including trimethoprim, [1] [2] cintriamide, roletamide, trimethoquinol (aka tretoquinol), and trimazosin as well as some psychedelic phenethylamines.
Monothiophosphate is used in research as an analogue of phosphate in biochemistry. Monothiophosphate esters are biochemical reagents used in the study of transcription, [4] substitution interference assays. Sometimes, "monothiophosphate" refers to esters such as (CH 3 O) 2 POS −. [5]
Trimethyl orthoformate (TMOF) is the organic compound with the formula HC(OCH 3) 3. A colorless liquid, it is the simplest orthoester. It is a reagent used in organic synthesis for the formation of methyl ethers. [3] The product of reaction of an aldehyde with trimethyl orthoformate is an acetal.
Tris is also used as a primary standard to standardize acid solutions for chemical analysis. Tris is used to increase permeability of cell membranes. [ 13 ] It is a component of the Moderna COVID-19 vaccine [ 14 ] and the Pfizer-BioNTech COVID-19 vaccine for use in children 5 through 11 years of age.