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Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. [1] It is a bactericidal agent. [1]The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure.
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Levofloxacin-based triple therapy 10 PPI (standard dose) bid, levofloxacin 0.5 g qd and amoxicillin 1 g bid Second line therapy if there is no fluoroquinolone resistance Culture-guided therapy 10 PPI (standard dose) bid, bismuth standard dose qid and two antibiotics selected by sensitivity tests
The cost of the full complement of tests is several million dollars per substance and it may take three or four years to complete. These toxicity tests provide, in the words of a 2006 United States National Academy of Sciences report, "critical information for assessing hazard and risk potential". [ 232 ]
Levofloxacin and other fluoroquinolones have also been widely used for the treatment of uncomplicated community-acquired respiratory and urinary tract infections, indications for which major medical societies generally recommend the use of older, narrower spectrum drugs to avoid fluoroquinolone resistance development.
[11] [18] Although antibiotics are effective in the curative treatment of chronic bacterial prostatitis, recurrence rates are high and range from 25 to 50%. [19] Levofloxacin (the levorotatory enantiomer of ofloxacin) has been found to reach prostatic fluid concentrations that are 5.5 times higher than those of the same dose of ciprofloxacin.
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Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. [5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene .
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