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RNFL asymmetry has been proposed as a strong indicator of optic neuritis, [7] [8] with one small study proposing that asymmetry of 5–6μm was "a robust structural threshold for identifying the presence of a unilateral optic nerve lesion in MS." [9] Optic neuritis is often associated with multiple sclerosis, and RNFL data may indicate the pace ...
The optic nerve contains axons of nerve cells that emerge from the retina, leave the eye at the optic disc, and go to the visual cortex where input from the eye is processed into vision. There are 1.2 million optic nerve fibers that derive from the retinal ganglion cells of the inner retina. [2] Damage to the optic nerve can have different causes:
The inferonasal retina are related to the anterior portion of the optic chiasm whereas superonasal retinal fibers are related to the posterior portion of the optic chiasm. The partial crossing over of optic nerve fibres at the optic chiasm allows the visual cortex to receive the same hemispheric visual field from both eyes.
Major symptoms are sudden loss of vision (partial or complete), sudden blurred or "foggy" vision, and; pain on movement of the affected eye. [4] [5] [2]Many patients with optic neuritis may lose some of their color vision in the affected eye (especially red), with colors appearing subtly washed out compared to the other eye.
Visual field-tubular vision Visual field-central scotoma. Lesions involving the whole optic nerve cause complete blindness on the affected side, that means damage at the right optic nerve causes complete loss of vision in the right eye. [3] Optic neuritis involving external fibers of the optic nerve causes tunnel vision. [4]
Optic nerve axons from one eye can only be selectively studied in the human after enucleation of the contralateral eye and thus degeneration of the axons on one side. After several years, the occurring optic nerve atrophy results in artifactual looping of the axons into the atrophic nerve.
The patient's vision returned to 20/40 and 20/60 from 20/60 and 20/200 in the right and left eyes respectively after only one month and was back normal by 8 months compared to the months to years timeframe seen in most cases.
Toxic optic neuropathy refers to the ingestion of a toxin or an adverse drug reaction that results in vision loss from optic nerve damage. Patients may report either a sudden loss of vision in both eyes, in the setting of an acute intoxication, or an insidious asymmetric loss of vision from an adverse drug reaction. The most important aspect of ...