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"Potentiates digitalis activity, increases coronary dilation effects of theophylline, caffeine, papaverine, sodium nitrate, adenosine and epinephrine, increase barbiturate-induced sleeping times" [3] Horse chestnut: conker tree, conker Aesculus hippocastanum: Liver toxicity, allergic reaction, anaphylaxis [3] Kava: awa, kava-kava [4] Piper ...
Kava or kava kava (Piper methysticum: Latin 'pepper' and Latinized Greek 'intoxicating') is a plant in the pepper family, native to the Pacific Islands. [1] The name kava is from Tongan and Marquesan , meaning 'bitter.’ [ 1 ] Other names for kava include ʻawa ( Hawaiʻi ), [ 2 ] ʻava ( Samoa ), yaqona or yagona ( Fiji ), [ 3 ] sakau ...
Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels. [1] How this effect is mediated, and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system, is unknown.
Research suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity. [2] Additionally, methysticin has been shown to potentiate GABA A receptor activity, contributing to the overall anxiolytic profile of the kava plant.
Biological Toxins such as Diphtheria toxin [18]; Radiation Therapy is known to cause radiation-induced heart disease (RIHD) [19] These agents can lead to varying degrees of cardiotoxicity, and their effects may be dose-dependent and influenced by individual factors such as pre-existing cardiovascular disease and genetic predispositions that can foster greater sensitivity to any cardiac damage.
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. [1] In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. [1] Heart rates above the resting rate may be normal (such as with exercise) or abnormal (such as with electrical problems within the heart).
Researchers have found that animals began to exhibit abnormal changes in blood flow after just one day of an artificially generated fast heart rate (designed to simulate a tachyarrythmia). [1] As their TIC progresses, these animals will have worsening heart function (e.g.: reduced cardiac output and reduced ejection fraction) for 3–5 weeks. [1]
Persons with congestive heart failure may be considered for surgical insertion of an ICD or a pacemaker which can improve heart function. In cases where the heart failure is irreversible and worsening, heart transplant may be considered. [7] Treatment will possibly prevent the heart from further deterioration, and the cardiomyopathy is largely ...