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Functional genomics uses mostly multiplex techniques to measure the abundance of many or all gene products such as mRNAs or proteins within a biological sample. A more focused functional genomics approach might test the function of all variants of one gene and quantify the effects of mutants by using sequencing as a readout of activity.
The key issue then is the translation of these newly identified genetic variants (from Copy Number Variant studies, candidate gene sequencing and high throughput sequencing technologies) into an intervention for patients with neurogenomic disorders. One aspect will be if the neurological disorder are medically actionable (i.e. is there a simple ...
For enzymes, predictions of specific functions are especially difficult, as they only need a few key residues in their active site, hence very different sequences can have very similar activities. By contrast, even with sequence identity of 70% or greater, 10% of any pair of enzymes have different substrates; and differences in the actual ...
Neuropsychological tests are specifically designed tasks that are used to measure a psychological function known to be linked to a particular brain structure or pathway. [1] Tests are used for research into brain function and in a clinical setting for the diagnosis of deficits.
Therefore, there are no aggregate measures or composite scores for an examinee's performance. A vast majority of these tests are modified, pre-existing measures (e.g., the Trail Making Test); however, some of these measures are new indices of executive functions (e.g., Word Context Test).
The Longhorns are facing No. 5 Georgia in the title game Saturday. The teams have two of college football's most famous mascots. There should be enough sideline space for Georgia's pure white ...
Schematic overview of the modular structure underlying procedures for gene set enrichment analysis. Gene set enrichment analysis (GSEA) (also called functional enrichment analysis or pathway enrichment analysis) is a method to identify classes of genes or proteins that are over-represented in a large set of genes or proteins, and may have an association with different phenotypes (e.g ...
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