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The Ferrier Lecture is a Royal Society lectureship given every three years "on a subject related to the advancement of natural knowledge on the structure and function of the nervous system". [1] It was created in 1928 to honour the memory of Sir David Ferrier , a neurologist who was the first British scientist to electronically stimulate the ...
PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
In his 50-year career, Ferrier published 180 papers, reviews and books, and gave 10 invited plenary lectures at international symposia. [15] His reviews were of particular benefit to the chemical community but perhaps of most value was the book "Monosaccharide Chemistry, [ 16 ] written with Dr Peter Collins in 1972 and majorly updated as ...
Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA inhibitors. [1] The antifungal flucytosine acts in a similar manner.
During DNA replication the ratio of nucleotides turned over to those stably incorporated into newly formed DNA is 10 to 100 times higher in the case of the tsB120 mutant than in wild-type. [8] It was proposed that the antimutator effect may be explained by both greater accuracy in nucleotide selection and an increased efficiency of removal of ...
Representational difference analysis (RDA) is a technique used in biological research to find sequence differences in two genomic or cDNA samples. Genomes or cDNA sequences from two samples (i.e. cancer sample and a normal sample) are PCR amplified and differences analyzed using subtractive DNA hybridization .
Bayraktar and Kreutz [39] found that DNMT inhibitors, applied in the brain, prevented long-term memories from forming. DNMT3L contains DNA methyltransferase motifs and is required for establishing maternal genomic imprints, despite being catalytically inactive. DNMT3L is expressed during gametogenesis when genomic imprinting takes place.
DNA gel electrophoresis is usually performed for analytical purposes, often after amplification of DNA via polymerase chain reaction (PCR), but may be used as a preparative technique prior to use of other methods such as mass spectrometry, RFLP, PCR, cloning, DNA sequencing, or southern blotting for further characterization.