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Propranolol was patented in 1962 and approved for medical use in 1964. [9] It is on the World Health Organization's List of Essential Medicines. [10] Propranolol is available as a generic medication. [2] In 2022, it was the 77th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [11] [12]
Nicergoline is known to enhance the cardiac depressive effects of propranolol. [6] At high dosages, it is advisable to seek one's physician's guidance if combining with potent vasodilators such as bromocriptine , Ginkgo biloba , picamilon , vinpocetine or xantinol nicotinate .
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
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[16] [18] [22] By comparison, labetalol is a weaker β-adrenergic receptor blocker than propranolol, and has a weaker affinity for α-adrenergic receptors compared to phentolamine. [19] [18] Labetalol's dual α- and β-adrenergic antagonism has different physiological effects in short- and long-term situations.
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To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
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