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John Haslam (1764–1844) was an English apothecary, physician and medical writer, known for his work on mental illness.Haslam's case study of James Tilly Matthews is the earliest detailed description of paranoid schizophrenia.
Schizophrenia was the last diagnosis to benefit from the link made between ACEs and adult mental health outcomes. [ 110 ] Living in an urban environment during childhood or as an adult has consistently been found to increase the risk of schizophrenia by a factor of two, [ 27 ] [ 111 ] even after taking into account drug use , ethnic group , and ...
Diagnosis of schizophrenia from all other diagnoses Sensitivity 57.0 (50.4, 63.3) Specificity 81.4 (74.0, 87.1) 48% (15% to 84%) Prevalence of 48%: 48 out of every 100 people with all other mental health diagnoses will have schizophrenia. The result means that, of these, 21 will not be identified as having schizophrenia by use of FRS (43% of 48).
Paraphrenia is often associated with a physical change in the brain, such as a tumor, stroke, ventricular enlargement, or neurodegenerative process. [4] Research that reviewed the relationship between organic brain lesions and the development of delusions suggested that "brain lesions which lead to subcortical dysfunction could produce delusions when elaborated by an intact cortex".
The management of schizophrenia usually involves many aspects including psychological, pharmacological, social, educational, and employment-related interventions directed to recovery, and reducing the impact of schizophrenia on quality of life, social functioning, and longevity.
A diagnosis of schizophrenia is not made at this time as it takes longer to be determined by both DSM-5 and ICD-11, and only around 60% of those presenting with a first episode of psychosis will later be diagnosed with schizophrenia. [33]
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