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By 1913 the name histamine was in use, using combining forms of histo-+ amine, yielding "tissue amine". "H substance" or "substance H" are occasionally used in medical literature for histamine or a hypothetical histamine-like diffusible substance released in allergic reactions of skin and in the responses of tissue to inflammation.
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
The treatment (in the form of subcutaneous injections) is given in 3-week cycles by the patients at home for 18 months, thus coinciding with the period of highest relapse risk. The side-effects include transient flush and headache , whereas IL-2 may induce low-grade fever and inflammation at the site of injection.
Treatment includes a healthy diet, salt restriction, and exercise. [2] The medication acetazolamide may also be used along with the above measures. [2] A small percentage of people may require surgery to relieve the pressure. [2] About 2 per 100,000 people are newly affected per year. [4] The condition most commonly affects women aged 20–50. [2]
There are more women than men with hypertension, [19] and, although men develop hypertension earlier in life, [20] hypertension in women is less well controlled. [21] [22] The consequences of high blood pressure in women are a major public health problem and hypertension is a more important contributory factor in heart attacks in women than men ...
Pharmacologic treatment will include antihypertensive medications. Options include sublingual or topical nitrates as well as oral hydralazine or clonidine. Ganglionic blockers can also be used to control sympathetic nervous system outflow. [29] [13] Epidural anesthesia has been demonstrated to be effective in reducing AD in women in labor ...
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine.In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response.
Angiotensin II receptor blockers are used primarily for the treatment of hypertension where the patient is intolerant of ACE inhibitor therapy primarily because of persistent and/or dry cough. [6] They do not inhibit the breakdown of bradykinin or other kinins , and are thus only rarely associated with the persistent dry cough and/or angioedema ...